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Consequently, the steady-state plasma level declines to a new value corresponding to the new rate of elimination. The drug effect may diminish or disappear. Conversely, when elimination is impaired (e. g. , in progressive renal insufficiency), the mean plasma level of renally eliminated drugs rises and may enter a toxic concentration range.
Approaches to ODT Development The fast disintegrating property of the tablet is attributable to a quick ingress of water into the tablet matrix resulting in its rapid disintegration. |
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